[4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate

Base Information

Chemical Name:[4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate
CAS No.:288570-86-5
Molecular Formula:C₂₁H₂₀Cl₂FNO₆S₂
Molecular Weight:536.429
Hs Code.:

Synonyms:[4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate

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Technology Process of [4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate

There total 1 articles about [4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 5402-73-3
2,5-dichlorobenzenesulphonyl chloride

: 288570-84-3
[4(R)-cis]-3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-5-(hydroxymethyl)-2-oxazolidinone

: 288570-86-5
[4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)00631-6

Reference yield:

: 288570-86-5
[4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate

: 216869-10-2
[4(R)-cis]-5-(aminomethyl)-3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxazolidinone

Guidance literature:: With ammonium hydroxide; In methanol;
DOI:10.1016/S0040-4039(00)00631-6

Reference yield:

: 288570-86-5
[4(R)-cis]-[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl-2,5-dichlorobenzenesulfonate

: [4(S)-cis]-N-[[3-[3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: NH₄OH / methanol

2: acetonitrile

With ammonium hydroxide; In methanol; acetonitrile; 1: ammonolysis / 2: Acetylation;
DOI:10.1016/S0040-4039(00)00631-6