(5R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxazolidinone

Base Information

Chemical Name:(5R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxazolidinone
CAS No.:168828-74-8
Molecular Formula:C₁₄H₁₆FN₅O₂S
Molecular Weight:337.378
Hs Code.:
DSSTox Substance ID:DTXSID401139391

Synonyms:ALWZKASVMYTTKY-NSHDSACASA-N;DTXSID401139391;(5R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxazolidinone;(R)-[[3-(3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]azide;168828-74-8

Suppliers and Price of (5R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (5R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxazolidinone

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:337.10087411
Heavy Atom Count:23
Complexity:484

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CSCCN1C2=C(C=C(C=C2)N3CC(OC3=O)CN=[N+]=[N-])F
Isomeric SMILES:C1CSCCN1C2=C(C=C(C=C2)N3C[C@@H](OC3=O)CN=[N+]=[N-])F

Technology Process of (5R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxazolidinone

There total 8 articles about (5R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 168828-73-7
Toluene-4-sulfonic acid (R)-3-(3-fluoro-4-thiomorpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester

: 168828-74-8
(R)-<3-<3-fluoro-4-(4-thiomorpholinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl azide

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 65 ℃; for 6h;
DOI:10.1021/jm950956y

Reference yield: 96.0%

: 174678-78-5
(R)-<3-<3-fluoro-4-(4-thiomorpholinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl methanesulfonate

: 168828-74-8
(R)-<3-<3-fluoro-4-(4-thiomorpholinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl azide

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 65 ℃; for 5h;
DOI:10.1021/jm950956y

Reference yield:

: 168828-70-4
(4-(2-fluoro-4-nitrophenyl)thiomorpholine)

: 168828-74-8
(R)-<3-<3-fluoro-4-(4-thiomorpholinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl azide

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / W-2 Raney nickel / H₂O; tetrahydrofuran / 2 h / 2068.6 Torr

2: NaHCO₃ / H₂O; tetrahydrofuran / 0.5 h

3: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min

4: 99 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 96 percent / NaN₃ / dimethylformamide / 5 h / 65 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; W-2 Raney nickel; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm950956y