2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone

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Chemical Name:2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone
CAS No.:1439314-73-4
Molecular Formula:C₃₂H₃₆FN₇O₃
Molecular Weight:585.681
Hs Code.:

Synonyms:2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone

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Chemical Property of 2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone

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Technology Process of 2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone

There total 7 articles about 2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-40-2
2-(morpholin-4-yl)ethanol

: 1439314-24-5
C₂₆H₂₄ClFN₆O

: 1439314-73-4
2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 - 200 ℃; for 0.75h; Microwave irradiation;

Reference yield:

: 180636-50-4
methyl 4-fluoro-3-methylbenzoate

: 1439314-73-4
2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C

1.2: 3 h / 20 °C

2.1: hydrazine / tetrahydrofuran / 3 h / 75 °C

3.1: potassium carbonate / acetone / 10 h / Reflux

4.1: lithium hydroxide; water / 1,4-dioxane / 6 h / 89 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.75 h / 120 - 200 °C / Microwave irradiation

With potassium tert-butylate; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1268047-31-9
1-(4-fluoro-3-methyl-phenyl)-3-phenyl-1,3-propanedione

: 1439314-73-4
2-[3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl]-1-{4-[6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-piperazin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine / tetrahydrofuran / 3 h / 75 °C

2: potassium carbonate / acetone / 10 h / Reflux

3: lithium hydroxide; water / 1,4-dioxane / 6 h / 89 °C

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.75 h / 120 - 200 °C / Microwave irradiation

With water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetone;