benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

Base Information

Chemical Name:benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside
CAS No.:340290-42-8
Molecular Formula:C₅₉H₆₂N₂O₁₃
Molecular Weight:1007.15
Hs Code.:

Synonyms:benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

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Chemical Property of benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

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Technology Process of benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

There total 8 articles about benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 340290-41-7
benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-4-O-phenoxyacetyl-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

: 340290-42-8
benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

Guidance literature:: With sodium methylate; In tetrahydrofuran; methanol;
DOI:10.1016/S0008-6215(01)00024-6

Reference yield:

: 216877-47-3
tert-butyldimethylsilyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleoylamido-glucopyranoside

: 340290-42-8
benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / pyridine / 2 h

2: 79 percent / TBAF; AcOH / tetrahydrofuran

3: 86 percent / DBU / CH₂Cl₂ / 2 h / 20 °C

4: 71 percent / TMSOTf / acetonitrile / 20 °C

5: 86 percent / AcOH; TBAF / tetrahydrofuran

6: 82 percent / DBU / CH₂Cl₂ / 2 h / 20 °C

7: 82 percent / TMSOTf / acetonitrile / 2 h / 20 °C

8: 82 percent / NaOMe / methanol; tetrahydrofuran

With pyridine; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; sodium methylate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0008-6215(01)00024-6

Reference yield:

: Phenoxy-acetic acid (2R,3S,4R,5R)-4-benzyloxy-2-benzyloxymethyl-5-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-6-hydroxy-tetrahydro-pyran-3-yl ester

: 340290-42-8
benzyl 3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-dimethylmaleimido-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / DBU / CH₂Cl₂ / 2 h / 20 °C

2: 71 percent / TMSOTf / acetonitrile / 20 °C

3: 86 percent / AcOH; TBAF / tetrahydrofuran

4: 82 percent / DBU / CH₂Cl₂ / 2 h / 20 °C

5: 82 percent / TMSOTf / acetonitrile / 2 h / 20 °C

6: 82 percent / NaOMe / methanol; tetrahydrofuran

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; sodium methylate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0008-6215(01)00024-6