N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

Base Information

Chemical Name:N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide
CAS No.:213540-89-7
Molecular Formula:C₃₃H₃₂F₂N₂O₂
Molecular Weight:526.626
Hs Code.:

Synonyms:N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

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Chemical Property of N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

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Technology Process of N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

There total 1 articles about N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 213540-84-2
N-octyl-2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxamide

: 2,3-dihydro-2-[4-(2-fluorophenyl)phenyl]-8-fluoro-1H-cyclopenta[c]quinoline-1-one

: 213540-89-7
N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

: C₆₆H₆₄F₄N₄O₄

Guidance literature:: With trifluorormethanesulfonic acid; at 130 ℃; for 4h;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield: 96.0%

: 213540-89-7
N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

: N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

Guidance literature:: N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide; With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

With hydrogen iodide; acetic anhydride; acetic acid; at 100 ℃; for 3h;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 213540-89-7
N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide

: 154015-73-3
10-fluoro-3-(2-fluoro-phenyl)-6,7-dihydro-5H-13-aza-benzo[3,4]cyclohepta[1,2-b]naphthalene-8-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaBH₄ / methanol / 1 h / 20 °C

1.2: 96 percent / Ac₂O; HI; AcOH / 3 h / 100 °C

2.1: NaNO₂; AcOH; Ac₂O / 20 °C

2.2: 74 percent / KOH / ethanol / 3 h / 80 °C

With sodium tetrahydroborate; acetic anhydride; acetic acid; sodium nitrite; In methanol;
DOI:10.1016/S0968-0896(01)00238-3