6-bromomethyl-3-phenylcoumarin

Base Information

• Chemical Name: 6-bromomethyl-3-phenylcoumarin
• CAS No.: 1253967-62-2
• Molecular Formula: C₁₆H₁₁BrO₂
• Molecular Weight: 315.166
• Mol file: 1253967-62-2.mol

Synonyms:6-bromomethyl-3-phenylcoumarin

Chemical Property of 6-bromomethyl-3-phenylcoumarin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromomethyl-3-phenylcoumarin

There total 5 articles about 6-bromomethyl-3-phenylcoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

phenylacetic acid (103-82-2) + 5-(bromomethyl)-2-hydroxybenzaldehyde (283170-46-7) → 6-bromomethyl-3-phenylcoumarin (1253967-62-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 100 - 110 ℃; for 24h;

DOI:10.1055/s-0029-1218835

Reference yield: 49.0%

6-methyl-3-phenylcoumarin (23000-31-9) → 6-bromomethyl-3-phenylcoumarin (1253967-62-2)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 18h; regioselective reaction; Reflux;

DOI:10.1055/s-0029-1218835

Reference yield:

p-cresol (106-44-5) → 6-bromomethyl-3-phenylcoumarin (1253967-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: boric acid / glycerol / 0.17 h / 150 - 160 °C

2: sodium carbonate / acetone / 6 h / Reflux

3: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 6 h / Reflux

With N-Bromosuccinimide; boric acid; sodium carbonate; dibenzoyl peroxide; In acetone; glycerol; benzene; 1: |Duff Aldehyde Synthesis;

DOI:10.1007/s00044-012-0159-y

upstream raw materials:

phenylacetic acid

5-(bromomethyl)-2-hydroxybenzaldehyde

6-methyl-3-phenylcoumarin

2-hydroxy-5-methylbenzaldehyde

Downstream raw materials:

6-formyl-3-phenylcoumarin