Technology Process of 5-(3,5-difluorobenzyloxy)-1H-pyrazolo[3,4-b]pyridin-3-amine
There total 5 articles about 5-(3,5-difluorobenzyloxy)-1H-pyrazolo[3,4-b]pyridin-3-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
isopropyl alcohol;
at 100 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0.17 h / 0 °C / Inert atmosphere
1.2: 2.5 h
2.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 20 h
3.1: trichlorophosphate / sulfuric acid / 110 °C
4.1: hydrazine hydrate / isopropyl alcohol / 6 h / 100 °C
With
sodium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
sulfuric acid;
In
ISOPROPYLAMIDE; isopropyl alcohol; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine hydrochloride / 2 h / 200 °C
2.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0.17 h / 0 °C / Inert atmosphere
2.2: 2.5 h
3.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 20 h
4.1: trichlorophosphate / sulfuric acid / 110 °C
5.1: hydrazine hydrate / isopropyl alcohol / 6 h / 100 °C
With
pyridine hydrochloride; sodium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
sulfuric acid;
In
ISOPROPYLAMIDE; isopropyl alcohol; acetonitrile; mineral oil;
