4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

Base Information

Chemical Name:4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide
CAS No.:1093256-09-7
Molecular Formula:C₁₉H₁₃Cl₂FN₄O₂
Molecular Weight:419.242
Hs Code.:

Synonyms:4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

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Chemical Property of 4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

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Technology Process of 4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

There total 7 articles about 4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.8%

: 1093262-22-6
4-chloro-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid

: 1093262-34-0
3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-methylbenzonitrile

: 1093256-09-7
4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

Guidance literature:: 4-chloro-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid; 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-methylbenzonitrile; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 25 ℃;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 72h;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1093256-09-7
4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 20 h / 125 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

3.1: sodium azide / dimethyl sulfoxide / 25 °C

4.1: water; triphenylphosphine / tetrahydrofuran / 16 h / 25 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; n-heptane / 1 h / 65 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 25 °C

6.2: 72 h / 25 °C

With N-Bromosuccinimide; sodium azide; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; n-heptane; dimethyl sulfoxide;

Reference yield:

: 1093262-11-3
3-bromo-5-[(6-chloro-2-fluoro-3-methylphenyl)oxy]benzonitrile

: 1093256-09-7
4-chloro-N-({4-chloro-3-[(3-cyano-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

2.1: sodium azide / dimethyl sulfoxide / 25 °C

3.1: water; triphenylphosphine / tetrahydrofuran / 16 h / 25 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; n-heptane / 1 h / 65 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 25 °C

5.2: 72 h / 25 °C

With N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; n-heptane; dimethyl sulfoxide;