(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester
CAS No.:1318264-93-5
Molecular Formula:C₄₇H₄₉Cl₃N₂O₆SSi
Molecular Weight:904.426
Hs Code.:

(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

Synonyms:(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

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Chemical Property of (R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

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Technology Process of (R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

There total 8 articles about (R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1318265-07-4
C₂₀H₁₈Cl₃NO₄S

: 1318264-92-4
(S)-3-iodo-2-(triphenylmethylamino)propionic acid (2-trimethylsilanyl)ethyl ester

: 1318264-93-5
(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 4h; Inert atmosphere;
DOI:10.1021/ol201548m

Reference yield:

: (R)-3-benzyloxy-2-tert-butoxycarbonylamino-propionic acid (2-trimethylsilanyl)ethyl ester

: 1318264-93-5
(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 4.5 h / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 103 h / 760.05 Torr

3.1: chloro-trimethyl-silane / dichloromethane / 0.33 h / Inert atmosphere; Reflux

3.2: 0.75 h / Reflux

4.1: triphenylphosphine; diethylazodicarboxylate; methyl iodide / dichloromethane / -10 - -2 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / Inert atmosphere

With chloro-trimethyl-silane; chlorotriisopropylsilane; palladium 10% on activated carbon; hydrogen; caesium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; methyl iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;
DOI:10.1021/ol201548m

Reference yield:

: 1318265-05-2
(R)-2-amino-3-hydroxy-propionic acid (2-trimethylsilanyl)ethyl ester

: 1318264-93-5
(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(S)-2-(2-trimethylsilanylethoxycarbonyl)-2-(triphenylmethylamino)ethylsulfanyl]propionic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane / dichloromethane / 0.33 h / Inert atmosphere; Reflux

1.2: 0.75 h / Reflux

2.1: triphenylphosphine; diethylazodicarboxylate; methyl iodide / dichloromethane / -10 - -2 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / Inert atmosphere

With chloro-trimethyl-silane; caesium carbonate; triphenylphosphine; diethylazodicarboxylate; methyl iodide; In dichloromethane; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;
DOI:10.1021/ol201548m