Technology Process of (1S,2S)-2-vinylcyclopropane-1,1-dicarboxylic acid isopropyl ester dibenzylamine salt
There total 4 articles about (1S,2S)-2-vinylcyclopropane-1,1-dicarboxylic acid isopropyl ester dibenzylamine salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-2-vinyl-cyclopropane-1,1-dicarboxylic acid diisopropyl ester;
With
tetramethyl ammoniumhydroxide;
In
water; isopropyl alcohol;
at 40 ℃;
for 6h;
dibenzylamine;
In
water; isopropyl alcohol;
for 0.5h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen; 10 wt% Pd(OH)2 on carbon / tetrahydrofuran; isopropyl alcohol / 20 °C
2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 1 h / 20 °C / Inert atmosphere; Cooling with ice
4.1: sodium hydride / methanol / 20 °C
5.1: triethylamine / dichloromethane / 2.5 h / 20 °C / Cooling with ice
6.1: sodium iodide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4.5 h / 80 °C
7.1: tetramethyl ammoniumhydroxide / water; isopropyl alcohol / 6 h / 40 °C
7.2: 0.5 h / Cooling with ice
With
10 wt% Pd(OH)2 on carbon; tetramethyl ammoniumhydroxide; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; sodium iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; paraffin oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 1 h / 20 °C / Inert atmosphere; Cooling with ice
3.1: sodium hydride / methanol / 20 °C
4.1: triethylamine / dichloromethane / 2.5 h / 20 °C / Cooling with ice
5.1: sodium iodide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4.5 h / 80 °C
6.1: tetramethyl ammoniumhydroxide / water; isopropyl alcohol / 6 h / 40 °C
6.2: 0.5 h / Cooling with ice
With
tetramethyl ammoniumhydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; sodium iodide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; paraffin oil;
