(R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide
CAS No.:1342803-91-1
Molecular Formula:C₂₅H₃₀F₂N₂OS₂
Molecular Weight:476.655
Hs Code.:

Synonyms:(R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide

There total 5 articles about (R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.1%

: 1342803-89-7
(R)-N-((5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)methylene)-2-methylpropane-2-sulfinamide

: 594-19-4
tert.-butyl lithium

: 1342803-91-1
(R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: (R)-N-((5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)methylene)-2-methylpropane-2-sulfinamide; tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 3h;

With methanol; In tetrahydrofuran; pentane; at -78 ℃;

With ammonium chloride; In tetrahydrofuran; pentane; at -78 ℃;

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 1342803-91-1
(R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(ll) bromide / ethyl acetate; chloroform / 6 h / Reflux

2.1: methanol / Reflux

2.2: 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h / 20 °C

5.1: pentane; tetrahydrofuran / 3 h / -78 °C

5.2: -78 °C

5.3: -78 °C

With titanium(IV) tetraethanolate; Dess-Martin periodane; copper(ll) bromide; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; pentane;

Reference yield:

: 292858-05-0
ethyl 3-bromo-2-oxo-4-phenylbutanoate

: 1342803-91-1
(R)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / Reflux

1.2: 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h / 20 °C

4.1: pentane; tetrahydrofuran / 3 h / -78 °C

4.2: -78 °C

4.3: -78 °C

With titanium(IV) tetraethanolate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; pentane;