cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

Base Information

Chemical Name:cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)
CAS No.:157800-20-9
Molecular Formula:C₃₉H₆₁N₃O₉
Molecular Weight:715.928
Hs Code.:

cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

Synonyms:cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

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Chemical Property of cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

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Technology Process of cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

There total 5 articles about cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 157800-34-5
C₅₂H₆₈F₅N₃O₁₀

: 157800-20-9
cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

Guidance literature:: With hydrogen; 4-pyrrolidin-1-ylpyridine; palladium on activated charcoal; In 1,4-dioxane; ethanol; at 95 ℃; for 10h;
DOI:10.1016/j.bmcl.2007.04.037

Reference yield:

: C₃₁H₅₀N₂O₇

: 157800-20-9
cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

Guidance literature:: Multi-step reaction with 4 steps

1: bis(2-oxo-3-oxazolidinyl)-phosphonic chloride; N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

2: HCl / 16 h / 0 - 20 °C

3: DCC / 4 h / 0 - 20 °C

4: 39 percent / H₂; 4-pyrrolidino-pyridine / Pd/C / dioxane; ethanol / 10 h / 95 °C

With hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 4-pyrrolidin-1-ylpyridine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.04.037

Reference yield:

: 157800-36-7
C₅₀H₇₇N₃O₁₀

: 157800-20-9
cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / 16 h / 0 - 20 °C

2: DCC / 4 h / 0 - 20 °C

3: 39 percent / H₂; 4-pyrrolidino-pyridine / Pd/C / dioxane; ethanol / 10 h / 95 °C

With hydrogenchloride; hydrogen; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1016/j.bmcl.2007.04.037