3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene

Base Information

Chemical Name:3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene
CAS No.:1170307-05-7
Molecular Formula:C₂₂H₃₂O₃
Molecular Weight:344.494
Hs Code.:

Synonyms:3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene

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Chemical Property of 3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene

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Technology Process of 3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene

There total 4 articles about 3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1170307-03-5
(3-isopropyl-2,4,5-trimethoxyphenyl)(2,6,6-trimethylcyclohex-1-en-1-yl)methanol

: 885482-29-1
(±)-7-isopropyl-5,6,8-trimethoxy-1,1,4a-trimethyl-2,3,4,4a-tetrahydro-1H-fluorene

: 1170307-05-7
3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene

Guidance literature:: With tin(II) trifluoromethanesulfonate; In dichloromethane; at 35 ℃; for 10h; Reagent/catalyst; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.tetlet.2016.06.030

Reference yield: 70.0%

: 1170307-03-5
(3-isopropyl-2,4,5-trimethoxyphenyl)(2,6,6-trimethylcyclohex-1-en-1-yl)methanol

: 1170307-05-7
3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene

Guidance literature:: With oxidant;
DOI:10.1016/j.tetlet.2009.02.074

Reference yield:

: 135-77-3
1,2,4-trimethoxy-benzene

: 1170307-05-7
3-isopropyl-1,2,4-trimethoxy-5-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0 °C / Inert atmosphere; Schlenk technique

2.1: tin(II) trifluoromethanesulfonate / dichloromethane / Inert atmosphere; Schlenk technique

3.1: palladium on activated charcoal; hydrogen / methanol / 760.05 Torr / Schlenk technique

4.1: N-Bromosuccinimide / dichloromethane / Inert atmosphere; Schlenk technique

5.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C / Inert atmosphere; Schlenk technique

5.2: 1.08 h / -78 °C / Inert atmosphere; Schlenk technique

6.1: tin(II) trifluoromethanesulfonate / dichloromethane / 10 h / 35 °C / Inert atmosphere; Schlenk technique

With N-Bromosuccinimide; tin(II) trifluoromethanesulfonate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; 6.1: |Nazarov Cyclization;
DOI:10.1016/j.tetlet.2016.06.030