methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate

Base Information

• Chemical Name: methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate
• CAS No.: 1357266-97-7
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.418
• Mol file: 1357266-97-7.mol

Synonyms:methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate

Chemical Property of methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate

There total 6 articles about methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(benzylamino)-3-methylcyclohex-2-en-1-one (1333144-37-8) + methyl 2-(chlorocarbonyl)pent-4-ynoate (1357266-64-8) → methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate (1357266-97-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol2033674

Reference yield:

potassium 2-(methoxycarbonyl)pent-4-ynoate (1357266-62-6) → methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate (1357266-97-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; water / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / pentane / 2 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; In dichloromethane; pentane;

DOI:10.1021/ol2033674

Reference yield:

2-(2-propynyl)malonic acid monomethyl ester (1096689-40-5) → methyl 2-[benzyl(2-methyl-4-oxocyclohex-2-en-1-yl)carbamoyl]pent-4-ynoate (1357266-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / pentane / 2 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; pentane;

DOI:10.1021/ol2033674

upstream raw materials:

2-(2-propynyl)malonic acid monomethyl ester

4-(benzylamino)-3-methylcyclohex-2-en-1-one

methyl 2-(chlorocarbonyl)pent-4-ynoate

potassium 2-(methoxycarbonyl)pent-4-ynoate