tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate
CAS No.:1390656-82-2
Molecular Formula:C₃₂H₃₉N₇O₆S
Molecular Weight:649.771
Hs Code.:

tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Synonyms:tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

There total 14 articles about tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1390656-82-2
tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: thionyl chloride / 5 h / 20 °C / Cooling with ice

2.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

5.2: 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: 1,4-dioxane / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 15 h / 120 °C

10.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 1 h / 120 °C / Microwave irradiation

With n-butyllithium; thionyl chloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; toluene-4-sulfonic acid; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

: 1390656-84-4
tert-butyl 4-(4-(7-chloro-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

: 76697-50-2
1-amino-2-(isopropylsulphonyl)benzene

: 1390656-82-2
tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: With potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1604-14-4
2,6-dichloroisonicotinic acid ethyl ester

: 1390656-82-2
tert-butyl 4-(4-(7-(2-(isopropylsulfonyl)phenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C

2.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

3.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux

4.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

4.2: 2 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: 1,4-dioxane / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 15 h / 120 °C

9.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 1 h / 120 °C / Microwave irradiation

With n-butyllithium; potassium tert-butylate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; toluene-4-sulfonic acid; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene; tert-butyl alcohol;