3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole

Base Information

• Chemical Name: 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole
• CAS No.: 122745-41-9
• Molecular Formula: C₁₈H₂₀ClNO₃
• Molecular Weight: 333.815
• Mol file: 122745-41-9.mol

Synonyms:3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole

Chemical Property of 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole

There total 48 articles about 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole (128300-11-8) → tert-butyl (1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indole-3-carboxylate (122745-41-9,130008-89-8,130007-86-2)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jo035465x

Reference yield: 97.5%

di-tert-butyl dicarbonate (24424-99-5) + Pro-CBI → tert-butyl (1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indole-3-carboxylate (122745-41-9,130008-89-8,130007-86-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 96.0%

N2-(tert-butyloxycarbonyl)-1,2,9,9a-tetrahydrocyclopropabenzindol-4-one (122745-32-8) → tert-butyl (1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indole-3-carboxylate (122745-41-9,130008-89-8,130007-86-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at -78 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/jo102136w

upstream raw materials:

5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole

(-)-(1S)-N-(tert-butyloxycarbonyl)-1-hydroxymethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole

di-tert-butyl dicarbonate

4-acetoxy-1-(acetylamino)-2-nitronaphthalene