(2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

Base Information

Chemical Name:(2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one
CAS No.:210887-74-4
Molecular Formula:C₂₇H₃₁NO₇
Molecular Weight:481.546
Hs Code.:

(2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

Synonyms:(2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

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Chemical Property of (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

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Technology Process of (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

There total 1 articles about (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 210887-73-3
(2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

: 210887-74-4
(2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

Guidance literature:: With ruthenium trichloride; sodium periodate; In water; ethyl acetate; acetonitrile; at 0 ℃; for 0.0833333h;
DOI:10.1016/S0040-4020(98)00158-6

Reference yield: 90.0%

: 1125-88-8
benzaldehyde dimethyl acetal

: 210887-74-4
(2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

: 210887-62-0
C₃₄H₃₅NO₇

Guidance literature:: With toluene-4-sulfonic acid; In acetonitrile; for 12h; Heating;
DOI:10.1016/S0040-4020(98)00158-6

Reference yield:

: 210887-74-4
(2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

: 210887-55-1
(2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / p-TsOH / acetonitrile / 12 h / Heating

2: 2 h / 300 °C / 2*10^-2 mbar

3: 88 percent / CH₂Cl₂ / 504 h / 4875390 Torr

4: 94 percent / H₂ / Pd/C / tetrahydrofuran / 5 h / Ambient temperature

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(98)00158-6