tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate

Base Information

• Chemical Name: tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate
• CAS No.: 1187627-06-0
• Molecular Formula: C₂₀H₂₇N₃O₂
• Molecular Weight: 341.453
• Mol file: 1187627-06-0.mol

Synonyms:tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate

Chemical Property of tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate

There total 1 articles about tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-Cyanobenzaldehyde (24964-64-5) + endo-3-<<(1,1-dimethylethoxy)carbonyl>amino>-8-azabicyclo<3.2.1>octane (132234-69-6) → tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate (1187627-06-0)

Guidance literature:

3-Cyanobenzaldehyde; endo-3-<<(1,1-dimethylethoxy)carbonyl>amino>-8-azabicyclo<3.2.1>octane; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 - 50 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 100.0%

tert-butyl 8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-ylcarbamate (1187627-06-0) → 3-((3-endo-amino-8-azabicyclo[3.2.1]octan-8-yl)methyl)benzonitrile dihydrochloride

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane;

upstream raw materials:

3-Cyanobenzaldehyde

endo-3-<<(1,1-dimethylethoxy)carbonyl>amino>-8-azabicyclo<3.2.1>octane