methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Base Information

Chemical Name:methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate
CAS No.:246158-14-5
Molecular Formula:C₄₆H₅₂N₆O₁₀
Molecular Weight:848.953
Hs Code.:

methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Synonyms:methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Suppliers and Price of methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

There total 17 articles about methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 246158-13-4
methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-tert-butoxycarbonylmethoxy-5-(4-tert-butoxyphenyl)pentyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

: 246158-14-5
methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Guidance literature:: With formic acid; at 20 ℃; for 20h;
DOI:10.1021/jo0356863

Reference yield:

: 246158-06-5
(2S,3S)-2-amino-1-(4-tert-butoxyphenyl)hex-5-en-3-ol

: 246158-14-5
methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / 4-(dimethylamino)pyridine; CuSO₄; triflyl azide / CH₂Cl₂ / 2 h

2: NaOH; NBu₄HSO₄ / benzene; H₂O / 1 h

3: 0.88 g / N-methylmorpholine oxide; OsO₄ / H₂O; acetone; tetrahydrofuran / 10 h

4: 85 percent / Na₂CO₃; Pb(OAc)4 / benzene / 3 h / 20 °C

5: 82 percent / triethylamine; NaBH(OAc)3 / 1,2-dichloro-ethane / 45 h

6: 85 percent / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tertramethyluronium*PF₆; diisopropylethylamine / dimethylformamide / 15 h / 20 °C

7: 99 percent / formic acid / 20 h / 20 °C

With lead(IV) acetate; dmap; sodium hydroxide; osmium(VIII) oxide; formic acid; triflic azide; tetra(n-butyl)ammonium hydrogensulfate; sodium tris(acetoxy)borohydride; sodium carbonate; copper(II) sulfate; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo0356863

Reference yield:

: 246158-07-6
(2S,3S)-2-azido-1-(4-tert-butoxyphenyl)hex-5-en-3-ol

: 246158-14-5
methyl (S)-2-((S)-2-[[(3S,4S)-4-azido-3-carboxymethoxy-5-(4-hydroxyphenyl)pentyl][2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-phenylpropionylamino)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH; NBu₄HSO₄ / benzene; H₂O / 1 h

2: 0.88 g / N-methylmorpholine oxide; OsO₄ / H₂O; acetone; tetrahydrofuran / 10 h

3: 85 percent / Na₂CO₃; Pb(OAc)4 / benzene / 3 h / 20 °C

4: 82 percent / triethylamine; NaBH(OAc)3 / 1,2-dichloro-ethane / 45 h

5: 85 percent / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tertramethyluronium*PF₆; diisopropylethylamine / dimethylformamide / 15 h / 20 °C

6: 99 percent / formic acid / 20 h / 20 °C

With lead(IV) acetate; sodium hydroxide; osmium(VIII) oxide; formic acid; tetra(n-butyl)ammonium hydrogensulfate; sodium tris(acetoxy)borohydride; sodium carbonate; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo0356863