(3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate

Base Information

Chemical Name:(3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate
CAS No.:1360555-32-3
Molecular Formula:C₂₆H₄₁N₃O₇
Molecular Weight:507.627
Hs Code.:

Synonyms:(3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate

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Chemical Property of (3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate

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Technology Process of (3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate

There total 3 articles about (3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1029649-48-6
tert-butyl (2-isocyanophenyl)carbamate

: 79069-51-5
(S)-N-tert-butoxycarbonylvalinal

: 107-92-6
butyric acid

: 1360555-32-3
(3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2011.12.073

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1360555-32-3
(3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 5.33 h / 0 - 20 °C

3: dichloromethane / 20 °C

With dmap; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; 3: Passerini reaction;
DOI:10.1016/j.tetlet.2011.12.073

Reference yield:

: 87694-52-8
tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate

: 1360555-32-3
(3S)-3-((tert-butoxycarbonyl)amino)-1-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-4-methyl-1-oxopentan-2-yl butyrate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5.33 h / 0 - 20 °C

2: dichloromethane / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; 2: Passerini reaction;
DOI:10.1016/j.tetlet.2011.12.073