2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

Base Information

Chemical Name:2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside
CAS No.:136738-72-2
Molecular Formula:C₃₁H₃₇ClO₆Si
Molecular Weight:569.17
Hs Code.:

Synonyms:2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

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Chemical Property of 2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

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Technology Process of 2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

There total 4 articles about 2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 136738-71-1
2-Chloroethyl 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

: 136738-72-2
2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86553-4

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 136738-72-2
2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

Guidance literature:: Multi-step reaction with 4 steps

1: 122 g / p-toluenesulfonic acid (pTsOH) / 12 h / Ambient temperature

2: 3.4percent KOH-MeOH / methanol / 3 h / Ambient temperature

3: 93.2 percent / imidazole / dimethylformamide / 0.5 h / Ambient temperature

4: 90.8 percent / PPTS / CH₂Cl₂ / 1 h / Ambient temperature

With 1H-imidazole; potassium hydroxide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86553-4

Reference yield:

: 64526-71-2,64949-99-1,64950-04-5
2-Chloroethyl β-D-ribofuranoside

: 136738-72-2
2-Chloroethyl 2'',3''-O-p-methoxybenzylidene 5''-O-tert-butyldiphenylsilyl-β-D-ribofuranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 93.2 percent / imidazole / dimethylformamide / 0.5 h / Ambient temperature

2: 90.8 percent / PPTS / CH₂Cl₂ / 1 h / Ambient temperature

With 1H-imidazole; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86553-4