5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Base Information

Chemical Name:5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile
CAS No.:1375262-92-2
Molecular Formula:C₁₈H₂₄N₄O
Molecular Weight:312.415
Hs Code.:

Synonyms:5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

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Chemical Property of 5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

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Technology Process of 5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

There total 5 articles about 5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2-amino-benzeneboronic acid hydrochloride

: 1375262-96-6
2-butyl-1-(2-hydroxy-2-methylpropyl)-5-iodo-1H-imidazole-4-carbonitrile

: 1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

: 1375262-92-2
5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ml300079e

Reference yield:

: 1375262-96-6
2-butyl-1-(2-hydroxy-2-methylpropyl)-5-iodo-1H-imidazole-4-carbonitrile

: 5570-18-3
2-aminophenylboronic acid

: 1375262-92-2
5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 919-29-9
triethyl orthovalerate

: 1375262-92-2
5-(2-aminophenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 5 h / 25 °C / Inert atmosphere; Reflux

1.2: 15 h / 25 °C / Inert atmosphere

2.1: diiodomethane; isopentyl nitrite / chloroform / 0.83 h / 80 °C / Inert atmosphere

3.1: palladium diacetate; sodium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 3 h / 100 °C / Inert atmosphere

With diiodomethane; palladium diacetate; sodium carbonate; triethylamine; triphenylphosphine; isopentyl nitrite; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water; 2.1: Sandmeyer reaction / 3.1: Suzuki coupling;
DOI:10.1021/ml300079e