Ethyl α--2-oxo-1-azetidineacetate

Base Information

Chemical Name:Ethyl α--2-oxo-1-azetidineacetate
CAS No.:70875-48-8
Molecular Formula:C₂₀H₂₁NO₄
Molecular Weight:339.391
Hs Code.:

Ethyl α-<p-(Benzyloxy)phenyl>-2-oxo-1-azetidineacetate

Synonyms:Ethyl α--2-oxo-1-azetidineacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl α--2-oxo-1-azetidineacetate

Chemical Property:

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Technology Process of Ethyl α--2-oxo-1-azetidineacetate

There total 6 articles about Ethyl α--2-oxo-1-azetidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 70875-42-2
2--N-(3-bromopropionyl)glycine Ethyl Ester

: 70875-48-8
Ethyl α--2-oxo-1-azetidineacetate

Guidance literature:: With sodium hydride; N,N-dimethyl-formamide; In dichloromethane; for 6.5h; Ambient temperature;
DOI:10.1021/jo00328a002

Reference yield:

: 43189-09-9,43189-39-5
2-(p-Hydroxyphenyl)glycine Ethyl Ester

: 70875-48-8
Ethyl α--2-oxo-1-azetidineacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) benzaldehyde, p-toluenesulfonyl acid, 2.) K₂CO₃ / 1.) DMF, 40 deg C, 12h, 2.) 60 deg C, 16h, 3.) EtOAc

2: 87 percent / N,N-dimethylaniline / CH₂Cl₂ / 1.) -20 deg C, 20 min, 2.) room temp., 1.5h

3: 80 percent / NaH, DMF / CH₂Cl₂ / 6.5 h / Ambient temperature

With sodium hydride; potassium carbonate; benzaldehyde; toluene-4-sulfonic acid; N,N-dimethyl-aniline; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jo00328a002

Reference yield:

: 70875-51-3
2-glycine Ethyl Ester Hydrotosylate

: 70875-48-8
Ethyl α--2-oxo-1-azetidineacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / N,N-dimethylaniline / CH₂Cl₂ / 1.) -20 deg C, 20 min, 2.) room temp., 1.5h

2: 80 percent / NaH, DMF / CH₂Cl₂ / 6.5 h / Ambient temperature

With sodium hydride; N,N-dimethyl-aniline; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jo00328a002