ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

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Chemical Name:ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
CAS No.:1269025-90-2
Molecular Formula:C₂₂H₂₃F₃N₂O₅
Molecular Weight:452.43
Hs Code.:

Synonyms:ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

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Chemical Property of ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

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Technology Process of ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

There total 10 articles about ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 150-19-6
O-methylresorcine

: 1269025-89-9
ethyl 6-ethyl-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

: 1269025-90-2
ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Guidance literature:: With pyridine; copper diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 883528-73-2
3-amino-4-methyl crotonic acid methylester

: 1269025-90-2
ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium ethanolate / ethanol / 15 h / 150 °C

2.1: trichlorophosphate / 0.5 h / 80 °C

3.1: hydrogen; triethylamine / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 5 h / 20 °C

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0 - 20 °C

5.1: trichlorophosphate / 12 h / Reflux

6.1: triethylamine / ethanol / 39 h / Reflux

6.2: 1 h / 20 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

8.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere

9.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 1 h / 100 °C

With pyridine; N-Bromosuccinimide; hydrogen; sodium ethanolate; potassium acetate; copper diacetate; caesium carbonate; triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1269024-70-5
ethyl 5-bromo-6-ethyl-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1269025-90-2
ethyl 6-ethyl-5-(3-methoxyphenoxy)-1-methyl-3-(2,2,2-trifluoroethoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 12 h / Reflux

2.1: triethylamine / ethanol / 39 h / Reflux

2.2: 1 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere

5.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 1 h / 100 °C

With pyridine; potassium acetate; copper diacetate; caesium carbonate; triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; N,N-dimethyl-formamide;