7-Chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide

Base Information

Chemical Name:7-Chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide
CAS No.:112634-53-4
Molecular Formula:C17H15 Cl F N3 O
Molecular Weight:331.7719
Hs Code.:
DSSTox Substance ID:DTXSID00920850

Synonyms:BRN 5121061;1H-1,4-Benzodiazepine-2-acetamide, 2,3-dihydro-7-chloro-5-(2-fluorophenyl)-;7-Chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide;112634-53-4;DTXSID00920850;LS-33992;2-[7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]ethanimidic acid

Suppliers and Price of 7-Chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 7-Chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide

Chemical Property:

Vapor Pressure:4.83E-12mmHg at 25°C
Boiling Point:547.6°C at 760 mmHg
Flash Point:285°C
Density:1.4g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:331.0887680
Heavy Atom Count:23
Complexity:473

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CC(=O)N

Technology Process of 7-Chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide

There total 2 articles about 7-Chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 112634-51-2
7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetic acid methyl ester

: 112634-53-4
7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide

Guidance literature:: With ammonia methyl alcohol; In methanol; at 100 ℃; for 17h; in a steel bomb;
DOI:10.1002/jhet.5570240327

Reference yield:

: 59468-40-5
7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

: 112634-53-4
7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / triethylsilane / trifluoroacetic acid / 0.5 h

2: 86 percent / 25percent (v/v) ammonia in methanol / methanol / 17 h / 100 °C / in a steel bomb

With triethylsilane; ammonia methyl alcohol; In methanol; trifluoroacetic acid;
DOI:10.1002/jhet.5570240327