(1S,2S,3S,4R)-3-(Hydroxymethyl)-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane

Base Information

• Chemical Name: (1S,2S,3S,4R)-3-(Hydroxymethyl)-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane
• CAS No.: 130464-39-0
• Molecular Formula: C₁₄H₁₉NO₃S
• Molecular Weight: 281.376

Synonyms:(1S,2S,3S,4R)-3-(Hydroxymethyl)-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane

Chemical Property of (1S,2S,3S,4R)-3-(Hydroxymethyl)-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane

Chemical Property:

Purity/Quality:

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Technology Process of (1S,2S,3S,4R)-3-(Hydroxymethyl)-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane

There total 2 articles about (1S,2S,3S,4R)-3-(Hydroxymethyl)-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-exo-carboxy-3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>heptane (100719-04-8,112918-04-4,125109-74-2,132747-46-7) → 2-exo-(hydroxymethyl)-3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>heptane (112918-05-5,122667-10-1,125109-75-3,130464-39-0,130464-44-7)

Guidance literature:

With diborane; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jm00165a022

Reference yield: 95.4%

(1S,2S,3S,4R)-3-Carboxy-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane (132747-46-7) → (1S,2S,3S,4R)-3-(Hydroxymethyl)-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane (130464-39-0)

Guidance literature:

With sodium tetrahydroborate; iodine; In 1,2-dimethoxyethane; at 10 ℃; for 0.5h;

DOI:10.1021/jo00006a030

Reference yield: 56.3%

2-exo-(hydroxymethyl)-3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>heptane (112918-05-5,122667-10-1,125109-75-3,130464-39-0,130464-44-7) → 2-exo-formyl-3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>heptane (112918-06-6,122667-14-5,125109-76-4,130464-40-3,130464-45-8)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1021/jm00165a022

upstream raw materials:

2-exo-carboxy-3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>heptane

(1S,2S,3S,4R)-3-Carboxy-2-((phenylsulfonyl)amino)bicyclo<2.2.1>heptane

Downstream raw materials:

2-exo-formyl-3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>heptane

N-((1S,2S,3S,4R)-3-Formyl-bicyclo[2.2.1]hept-2-yl)-benzenesulfonamide

(3'R,4'R,5'S,6'S)-5'-(Formylmethyl)-4'-benzenesulfonamidobicyclo<2.2.1>heptane

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