Technology Process of Ethyl 2,2-bis(3-iodopropyl)-2-phenylpentanoate
There total 4 articles about Ethyl 2,2-bis(3-iodopropyl)-2-phenylpentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 45 min, 2.) room temp., 1 h
2: 1.) cyclohexene, BH3*SMe2, 2.) NaOAc, ICl / 1.) THF, 0 deg C, 1 h; room temp., 1 h, 2.) MeOH, 0 deg C, 1 h
3: 89 percent / NaI / acetone / 15 h / Heating
With
dimethylsulfide borane complex; sodium acetate; Iodine monochloride; sodium iodide; lithium diisopropyl amide; cyclohexene;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone;
DOI:10.1021/jo00077a053
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / LDA / hexamethylphosphoric acid triamide; tetrahydrofuran / 1.) -78 deg C, 45 min, 2.) 0 deg C, 30 min
2: 85 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 45 min, 2.) room temp., 1 h
3: 1.) cyclohexene, BH3*SMe2, 2.) NaOAc, ICl / 1.) THF, 0 deg C, 1 h; room temp., 1 h, 2.) MeOH, 0 deg C, 1 h
4: 89 percent / NaI / acetone / 15 h / Heating
With
dimethylsulfide borane complex; sodium acetate; Iodine monochloride; sodium iodide; lithium diisopropyl amide; cyclohexene;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone;
DOI:10.1021/jo00077a053
