girodazole

Base Information

• Chemical Name: girodazole
• CAS No.: 135824-74-7
• Molecular Formula: C₆H₁₁ClN₄O*2ClH
• Molecular Weight: 263.554
• Mol file: 135824-74-7.mol

Synonyms:1H-Imidazole-4-methanol,2-amino-a-(2-amino-1-chloroethyl)-,dihydrochloride, [S-(R*,R*)]-; 1H-Imidazole-4-methanol, 2-amino-a-[(1S)-2-amino-1-chloroethyl]-,dihydrochloride, (aS)- (9CI); Girodazole; Girolline hydrochloride; NSC 627434; RP 49532A

Chemical Property of girodazole

Chemical Property:

• Vapor Pressure: 2.97E-11mmHg at 25°C
• Boiling Point: 510.7°Cat760mmHg
• Flash Point: 262.7°C
• PSA: 101.68000
• Density: g/cm³
• LogP: 1.82580

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of girodazole

There total 6 articles about girodazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

{(2S,3S)-2-Chloro-3-[2-(4-chloro-phenylazo)-1H-imidazol-4-yl]-3-hydroxy-propyl}-carbamic acid tert-butyl ester (135910-49-5) → girolline (127909-96-0,132618-95-2,135824-74-7)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; at 20 ℃; for 24h; under 760 Torr;

DOI:10.1016/S0040-4039(00)93492-0

Reference yield:

[(2S,3S)-2-Chloro-3-hydroxy-3-(1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester (135910-48-4) → girolline (127909-96-0,132618-95-2,135824-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) aq. Na₂CO₃ / 1) MeOH, 2 deg C, 2) H₂O, 2 deg C, 20 min

2: 45 percent / H₂, HCl / PtO₂ / methanol / 24 h / 20 °C / 760 Torr

With hydrogenchloride; hydrogen; sodium carbonate; platinum(IV) oxide; In methanol;

DOI:10.1016/S0040-4039(00)93492-0

Reference yield:

(1S,2S)-3-Amino-2-chloro-1-(1-trityl-1H-imidazol-4-yl)-propan-1-ol (135910-46-2) → girolline (127909-96-0,132618-95-2,135824-74-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / CH₂Cl₂ / 1 h / 20 °C

2: 90 percent / HOAc / propan-1-ol / 24 h / Heating

3: 1) aq. Na₂CO₃ / 1) MeOH, 2 deg C, 2) H₂O, 2 deg C, 20 min

4: 45 percent / H₂, HCl / PtO₂ / methanol / 24 h / 20 °C / 760 Torr

With hydrogenchloride; hydrogen; sodium carbonate; acetic acid; platinum(IV) oxide; In methanol; propan-1-ol; dichloromethane;

DOI:10.1016/S0040-4039(00)93492-0

upstream raw materials:

{(2S,3S)-2-Chloro-3-[2-(4-chloro-phenylazo)-1H-imidazol-4-yl]-3-hydroxy-propyl}-carbamic acid tert-butyl ester

[(2S,3S)-2-Chloro-3-hydroxy-3-(1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester

(1S,2S)-3-Amino-2-chloro-1-(1-trityl-1H-imidazol-4-yl)-propan-1-ol

(2R,3S)-2-Chloro-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Refernces