3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester

Base Information

• Chemical Name: 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester
• CAS No.: 84532-30-9
• Molecular Formula: C₂₈H₂₄N₂O₅S
• Molecular Weight: 500.575
• Mol file: 84532-30-9.mol

Synonyms:3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester

Chemical Property of 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester

There total 2 articles about 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R)-3-methylene-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid (37794-96-0,54240-49-2) + diazodiphenylmethane (908093-98-1) → 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester (84532-30-9)

Guidance literature:

With ozone; Yield given. Multistep reaction; 1.) MeOH, 5 min, -65 deg C, 2.) MeOH, room temperature, 1 h;

DOI:10.1248/cpb.36.582

Reference yield:

→ 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester (84532-30-9)

Guidance literature:

α-<3-Benzyl-7-oxo-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>-α-(1-hydroxyethyliden)essigsaeure-benzhydrylester; 1) Mesylchlorid / NEt3; 2) Morpholin; 3) Br2 / Pyridin; 4) H2O / HCl; Bsp. 16.-III;

Reference yield: 90.6%

3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester (84532-30-9) → C28H26N2O5S (51762-51-7,51820-24-7)

Guidance literature:

With potassium borohydride; In methanol; dichloromethane; at -60 - -50 ℃; for 2.33h;

upstream raw materials:

(6R)-3-methylene-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid

diazodiphenylmethane

Downstream raw materials:

C₂₈H₂₆N₂O₅S