(S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea

Base Information

Chemical Name:(S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea
CAS No.:1194044-47-7
Molecular Formula:C₁₈H₁₇BrF₂N₂O₂S
Molecular Weight:443.312
Hs Code.:

Synonyms:(S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea

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Technology Process of (S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea

There total 1 articles about (S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194044-43-3
(S)-3-amino-3-(5-bromo-2,4-difluorophenyl)butan-1-ol

: 532-55-8
Benzoyl isothiocyanate

: 1194044-47-7
(S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea

Guidance literature:: (S)-3-amino-3-(5-bromo-2,4-difluorophenyl)butan-1-ol; With 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide; In tetrahydrofuran; for 2h;

Benzoyl isothiocyanate; In tetrahydrofuran;

Reference yield:

: 1194044-47-7
(S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea

: 1194044-52-4
(S)-4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: (S)-1-benzoyl-3-[1-(5-bromo-2,4-difluoro-phenyl)-3-hydroxy-1-methyl-propyl]-thiourea; With hydrogenchloride; water; In 1,4-dioxane; at 100 ℃;

With hydrogenchloride; water; at 100 ℃; for 18h;

With sodium hydroxide; In water; at 10 ℃; pH=10;