(R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

Base Information

Chemical Name:(R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile
CAS No.:252357-37-2
Molecular Formula:C₂₉H₂₉F₂N₂O₃P
Molecular Weight:522.531
Hs Code.:

Synonyms:(R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

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Chemical Property of (R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

Chemical Property:

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Technology Process of (R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

There total 2 articles about (R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 43055-47-6
(α-cyanoethylidene)triphenylphosphorane

: 252357-33-8
(R,S)-(2-N-(tert-butoxycarbonyl)-amino)-4,4-difluoro-butyric N-methyl-O-methylcarboxamide

: 252357-37-2
(R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield: 54.0%

: 16640-68-9
cyanomethylene triphenylphosphorane

: 252357-43-0
2-{[(tert-butoxy)carbonyl]amino}-4,4-difluorobutanoic acid

: 252357-37-2
(R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/S0960-894X(01)00843-5

Reference yield:

: 252357-37-2
(R,S)-4-(tert-butyloxycarbonylamino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

: (R)-3-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentanoylamino]-5,5-difluoro-2-hydroxy-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: O₃ / CH₂Cl₂ / -78 °C

2: NaBH₄ / methanol

3: HCl / ethyl acetate

4: EDCI; HOBt; iPr₂NEt / CH₂Cl₂

5: NaOH / methanol

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00843-5