tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate

Base Information

Chemical Name:tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate
CAS No.:1427565-56-7
Molecular Formula:C₂₆H₂₇FO₅S
Molecular Weight:470.562
Hs Code.:

Synonyms:tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate

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Chemical Property of tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate

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Technology Process of tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate

There total 6 articles about tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1427565-55-6
tert-butyl 2-(2-(4'-hydroxybiphenyl-4-ylsulfonyl)phenyl)acetate

: 383-50-6
2-fluoroethyl tosylate

: 1427565-56-7
tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 82 ℃; Inert atmosphere;
DOI:10.1021/jm4001743

Reference yield:

: 13420-80-9
[2-(4-bromo-phenylsulfanyl)phenyl]acetic acid

: 1427565-56-7
tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 3 h / 95 °C

2: oxone||potassium monopersulfate triple salt / water; methanol; tetrahydrofuran / 20 h

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 5 h / 85 °C / Inert atmosphere

4: potassium carbonate / acetonitrile / 82 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxone||potassium monopersulfate triple salt; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1021/jm4001743

Reference yield:

: 1427565-52-3
tert-butyl 2-(2-(4-bromophenylthio)phenyl)acetate

: 1427565-56-7
tert-butyl 2-(2-(4'-(2-fluoroethoxy)biphenyl-4-ylsulfonyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: oxone||potassium monopersulfate triple salt / water; methanol; tetrahydrofuran / 20 h

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 5 h / 85 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 82 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxone||potassium monopersulfate triple salt; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1021/jm4001743