8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione

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Chemical Name:8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione
CAS No.:1628222-60-5
Molecular Formula:C₂₅H₁₉N₅O₅S₂
Molecular Weight:533.588
Hs Code.:

Synonyms:8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione

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Chemical Property of 8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione

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Technology Process of 8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione

There total 4 articles about 8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 75-15-0,12122-00-8
carbon disulfide

: 1628222-56-9
2-hydrazinyl-7-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-5-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine-4(3H)-thione

: 1628222-60-5
8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione

Guidance literature:: With sodium hydroxide; In ethanol; at 80 ℃; for 8h;
DOI:10.1515/hc-2013-0199

Reference yield:

: 1628222-48-9
7-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-5-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dithione

: 1628222-60-5
8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / ethanol; water / 20 °C / Heating

1.2: 2 h / Heating

2.1: hydrazine hydrate / ethanol / 8 h / Heating

3.1: sodium hydroxide / ethanol / 8 h / 80 °C

With sodium hydrogencarbonate; hydrazine hydrate; sodium hydroxide; In ethanol; water;
DOI:10.1515/hc-2013-0199

Reference yield:

: 1628222-40-1
2-amino-6-(5-hydroxy-4,7-dimethoxy-1-benzofuran-6-yl)-4-(4-methoxyphenyl)nicotinonitrile

: 1628222-60-5
8-(5-hydroxy-4,7-dimethoxybenzofuran-6-yl)-3-mercapto-6-(4-methoxyphenyl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5(1H)-thione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / ethanol; water / 2 h / Reflux

1.2: 2 h / Heating

2.1: sodium hydrogencarbonate / ethanol; water / 20 °C / Heating

2.2: 2 h / Heating

3.1: hydrazine hydrate / ethanol / 8 h / Heating

4.1: sodium hydroxide / ethanol / 8 h / 80 °C

With sodium hydrogencarbonate; hydrazine hydrate; sodium hydroxide; In ethanol; water;
DOI:10.1515/hc-2013-0199