(2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Base Information

Chemical Name:(2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine
CAS No.:262845-99-8
Molecular Formula:C₂₀H₂₆N₂O₇S
Molecular Weight:438.502
Hs Code.:

Synonyms:(2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Suppliers and Price of (2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

There total 30 articles about (2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 263155-24-4
Methanesulfonic acid (1R,3R)-3-allyloxycarbonylamino-3-[4-(allyloxycarbonylamino-methyl)-phenyl]-1-methanesulfonyloxymethyl-propyl ester

: 262845-99-8
(2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -20 ℃;
DOI:10.1248/cpb.48.310

Reference yield:

: 87736-74-1
4-(tert-butyldimethylsiloxymethyl)bromobenzene

: 262845-99-8
(2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Guidance literature:: Multi-step reaction with 15 steps

1: 88 percent / n-BuLi / tetrahydrofuran / -70 °C

2: 88 percent / tetrapropylammonium perruthenate; 4-methylmorpholine / CH₂Cl₂

3: NaBH₄ / methanol / 0 °C

4: TEA / CH₂Cl₂ / 0 °C

5: NaN₃ / dimethylformamide / 50 °C

6: PPh₃; water / tetrahydrofuran / 20 °C

7: TEA / tetrahydrofuran / 0 °C

8: n-Bu₄NF / tetrahydrofuran / 0 °C

9: TEA / CH₂Cl₂ / 0 °C

10: NaN₃ / dimethylformamide / 20 °C

11: PPh₃; H₂₀ / tetrahydrofuran / 20 °C

12: TEA / tetrahydrofuran / 0 °C

13: p-TsOH / methanol / 20 °C

14: TEA / CH₂Cl₂ / 0 °C

15: 97 percent / t-BuOK / tetrahydrofuran / -20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; n-butyllithium; sodium azide; tetrapropylammonium perruthennate; TEA; potassium tert-butylate; tetrabutyl ammonium fluoride; water; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.310

Reference yield:

: 228267-27-4
(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutanol

: 262845-99-8
(2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Guidance literature:: Multi-step reaction with 14 steps

1: 88 percent / tetrapropylammonium perruthenate; 4-methylmorpholine / CH₂Cl₂

2: NaBH₄ / methanol / 0 °C

3: TEA / CH₂Cl₂ / 0 °C

4: NaN₃ / dimethylformamide / 50 °C

5: PPh₃; water / tetrahydrofuran / 20 °C

6: TEA / tetrahydrofuran / 0 °C

7: n-Bu₄NF / tetrahydrofuran / 0 °C

8: TEA / CH₂Cl₂ / 0 °C

9: NaN₃ / dimethylformamide / 20 °C

10: PPh₃; H₂₀ / tetrahydrofuran / 20 °C

11: TEA / tetrahydrofuran / 0 °C

12: p-TsOH / methanol / 20 °C

13: TEA / CH₂Cl₂ / 0 °C

14: 97 percent / t-BuOK / tetrahydrofuran / -20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; sodium azide; tetrapropylammonium perruthennate; TEA; potassium tert-butylate; tetrabutyl ammonium fluoride; water; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.310