5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine
• CAS No.: 439115-29-4
• Molecular Formula: C₄₁H₄₅N₅O₁₁
• Molecular Weight: 783.835

Synonyms:5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine

There total 6 articles about 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(3,4-diacetoxybut-1-yl)-N2-acetyl-2'-deoxyguanosine (439115-27-2) → 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N2-acetyl-2'-deoxyguanosine (439115-29-4)

Guidance literature:

With pyridine; at 20 ℃; for 5h;

DOI:10.1021/tx010181y

Reference yield:

2'-Deoxyguanosine (961-07-9) → 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N2-acetyl-2'-deoxyguanosine (439115-29-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaOH / N,N-dimethyl-acetamide / 1 h / 70 °C

1.2: 65 percent / N,N-dimethyl-acetamide / 20 - 60 °C

2.1: 90 percent / 1H-imidazole / dimethylformamide

3.1: 87 percent / N-methylmorpholine-N-oxide; OsO₄ / tetrahydrofuran; H₂O / 20 °C

4.1: 84 percent / triethylamine; 4-(dimethylamino)pyridine / pyridine / 80 h / 55 °C

5.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: 73 percent / pyridine / 5 h / 20 °C

With pyridine; 1H-imidazole; dmap; sodium hydroxide; osmium(VIII) oxide; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; pyridine; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

DOI:10.1021/tx010181y

Reference yield:

1-(3-butenyl)-2'-deoxyguanosine (439115-15-8) → 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N2-acetyl-2'-deoxyguanosine (439115-29-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / 1H-imidazole / dimethylformamide

2: 87 percent / N-methylmorpholine-N-oxide; OsO₄ / tetrahydrofuran; H₂O / 20 °C

3: 84 percent / triethylamine; 4-(dimethylamino)pyridine / pyridine / 80 h / 55 °C

4: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: 73 percent / pyridine / 5 h / 20 °C

With pyridine; 1H-imidazole; dmap; osmium(VIII) oxide; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide;

DOI:10.1021/tx010181y

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine

2'-Deoxyguanosine

1-(3-butenyl)-2'-deoxyguanosine

Downstream raw materials:

3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 439115-29-4 5'-O-(4,4'-dimethoxytrityl)-1-(3,4-diacetoxybut-1-yl)-N²-acetyl-2'-deoxyguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send