5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine

Base Information

Chemical Name:5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine
CAS No.:194729-28-7
Molecular Formula:C₁₈H₁₂N₄O₄
Molecular Weight:348.318
Hs Code.:

Synonyms:5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine

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Chemical Property of 5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine

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Technology Process of 5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine

There total 8 articles about 5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 862457-87-2
(2,2-dimethoxy-ethyl)-[5-(4-nitro-phenyl)-7,9-dihydro-1,3-dioxa-6,7-diaza-cyclohepta[f]inden-8-ylidene]-amine

: 194729-28-7
5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine

Guidance literature:: With hydrogenchloride; In ethanol; for 3h; Heating;
DOI:10.1021/jm0580003

Reference yield:

: 53732-94-8
5-(4-Nitrophenyl)-1,3-dioxolo[4,5-g]-isochroman

: 194729-28-7
5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 52 percent / aq. H₂SO₄; CrO₃ / acetone / 15 - 20 °C

2.1: Et₃N; isobutyl chloroformate / tetrahydrofuran / -20 °C

2.2: 75 percent / hydrazine hydrate / tetrahydrofuran / 20 °C

3.1: 79 percent / phosphorus pentasulfide / pyridine / Heating

4.1: 72 percent / 2-methoxy-ethanol / 3 h / 110 °C

5.1: 80 percent / aq. HCl / ethanol / 3 h / Heating

With chromium(VI) oxide; hydrogenchloride; diphosphorus pentasulfide; sulfuric acid; triethylamine; isobutyl chloroformate; In tetrahydrofuran; pyridine; ethanol; 2-methoxy-ethanol; acetone; 1.1: Jones oxidation;
DOI:10.1021/jm0580003

Reference yield:

: 194729-09-4
2-(4-nitro-benzoyl)-4,5-(methylenedioxy)-phenyl acetic acid

: 194729-28-7
5-(4-Nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2.3]benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N; isobutyl chloroformate / tetrahydrofuran / -20 °C

1.2: 75 percent / hydrazine hydrate / tetrahydrofuran / 20 °C

2.1: 79 percent / phosphorus pentasulfide / pyridine / Heating

3.1: 72 percent / 2-methoxy-ethanol / 3 h / 110 °C

4.1: 80 percent / aq. HCl / ethanol / 3 h / Heating

With hydrogenchloride; diphosphorus pentasulfide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; pyridine; ethanol; 2-methoxy-ethanol;
DOI:10.1021/jm0580003