(R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid

Base Information

• Chemical Name: (R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid
• CAS No.: 77284-61-8
• Molecular Formula: C₂₀H₂₃NO₅
• Molecular Weight: 357.406
• Mol file: 77284-61-8.mol

Synonyms:(R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid

Chemical Property of (R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid

There total 5 articles about (R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

tert-butyldicarbonate (34619-03-9) + (R/S)-4-(aminophenylmethyl)phenoxyacetic acid (81123-43-5) → (R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid (77284-61-8)

Guidance literature:

(R/S)-4-(aminophenylmethyl)phenoxyacetic acid; With potassium carbonate; In water; at 20 ℃; Heating;

tert-butyldicarbonate; In tetrahydrofuran; water; for 1h;

DOI:10.1002/psc.1248

Reference yield:

4-(hydroxyiminophenymethyl)phenoxyacetic acid (503038-36-6) → (R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid (77284-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium / ethanol / Reflux

2.1: potassium carbonate / water / 20 °C / Heating

2.2: 1 h

With sodium; potassium carbonate; In ethanol; water;

DOI:10.1002/psc.1248

Reference yield:

(4-OH)-benzhydrylamine (81123-45-7) → (R/S)-4-(tert-butoxycarbonylaminophenylmethyl)phenoxyacetic acid (77284-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine

2: ethanol; water

With triethylamine; In ethanol; water;

DOI:10.1002/psc.1279

upstream raw materials:

4-(hydroxyiminophenymethyl)phenoxyacetic acid

tert-butyldicarbonate

(R/S)-4-(aminophenylmethyl)phenoxyacetic acid

(4-hydroxyphenyl)(phenyl)methanone oxime