tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate
CAS No.:911418-69-4
Molecular Formula:C₃₆H₃₅N₇O₆
Molecular Weight:661.717
Hs Code.:

Synonyms:tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

There total 6 articles about tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911418-64-9
tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(nicotinamido)-phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 6482-24-2
2-Bromoethyl methyl ether

: 911418-69-4
tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 3h;

Reference yield:

: 911418-47-8
4-chloro-7-methoxy-2-(3-nitrophenyl)quinazolin-6-yl acetate

: 911418-69-4
tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 5 h / Heating / reflux

2: hydrogen / palladium over charcoal / methanol / 48 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C

4: methanol; ammonia; water / 24 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 85 °C

With methanol; ammonia; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium over charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 911418-46-7
7-methoxy-2-(3-nitrophenyl)-4-oxo-3,4-dihydroquinazolin-6-yl acetate

: 911418-69-4
tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride; N,N-dimethyl-formamide / 2.5 h / Heating / reflux

2: isopropyl alcohol / 5 h / Heating / reflux

3: hydrogen / palladium over charcoal / methanol / 48 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C

5: methanol; ammonia; water / 24 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 3 h / 85 °C

With methanol; thionyl chloride; ammonia; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; palladium over charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;