(4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid

Base Information

Chemical Name:(4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid
CAS No.:84520-90-1
Molecular Formula:C₁₉H₂₄N₂O₇
Molecular Weight:392.409
Hs Code.:

Synonyms:(4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid

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Chemical Property of (4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid

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Technology Process of (4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid

There total 6 articles about (4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 84520-88-7
(4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

: 84520-90-1
(4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid

Guidance literature:: With hydrogen fluoride; methoxybenzene; at 0 ℃; for 0.833333h;
DOI:10.1021/jm00358a017

Reference yield:

: 84520-71-8
(4S)-1-butyryl-1-azido-L-proline methyl ester

: 84520-90-1
(4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: concd. HCl, H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

2: dioxane / 48 h / 50 °C

3: 96 percent / NaBH₃CN / acetonitrile / 0.25 h / Ambient temperature

4: 77 percent / NaOH / methanol / 3 h / Ambient temperature

5: 83 percent / DCC, DMAP / CH₂Cl₂ / Ambient temperature

6: 43 percent / anisole, HF / 0.83 h / 0 °C

With hydrogenchloride; dmap; sodium hydroxide; hydrogen fluoride; hydrogen; sodium cyanoborohydride; methoxybenzene; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00358a017

Reference yield:

: 84520-73-0
(2S,4S)-4-Amino-1-butyryl-pyrrolidine-2-carboxylic acid methyl ester

: 84520-90-1
(4S)-1-butyryl-4-<(carboxymethyl)methylamino>-L-proline 2-ester with salicylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dioxane / 48 h / 50 °C

2: 96 percent / NaBH₃CN / acetonitrile / 0.25 h / Ambient temperature

3: 77 percent / NaOH / methanol / 3 h / Ambient temperature

4: 83 percent / DCC, DMAP / CH₂Cl₂ / Ambient temperature

5: 43 percent / anisole, HF / 0.83 h / 0 °C

With dmap; sodium hydroxide; hydrogen fluoride; sodium cyanoborohydride; methoxybenzene; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00358a017