1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one

Base Information

• Chemical Name: 1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one
• CAS No.: 725211-47-2
• Molecular Formula: C₂₄H₂₉NO₄S
• Molecular Weight: 427.565
• Mol file: 725211-47-2.mol

Synonyms:1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one

Chemical Property of 1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one

There total 4 articles about 1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-Thiophenecarbonyl chloride (5271-67-0) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + hex-1-yne (693-02-7) + acryloyl chloride (814-68-6,25189-84-8) → 1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one (725211-47-2)

Guidance literature:

2-Thiophenecarbonyl chloride; hex-1-yne; With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

2-(3,4-dimethoxyphenyl)-ethylamine; In tetrahydrofuran; at 70 ℃; for 10h;

acryloyl chloride; In tetrahydrofuran; at 70 ℃; for 3h;

DOI:10.1039/b404559a

Reference yield:

2-Thiophenecarbonyl chloride (5271-67-0) → 1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one (725211-47-2)

Guidance literature:

Multi-step reaction with 3 steps

1: CuI; Et₃N / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 2 h / 20 °C

2: tetrahydrofuran / 24 h / 70 °C

3: 295 mg / tetrahydrofuran / 3 h / 70 °C

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1: Sonogashira coupling;

DOI:10.1039/b511861a

Reference yield:

3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-1-thiophen-2-yl-hept-2-en-1-one + acryloyl chloride (814-68-6,25189-84-8) → 1-[3,4-dimethoxyphenylethyl]-6-butyl-5-(thiophene-2-carbonyl)-3,4-dihydro-1H-pyridin-2-one (725211-47-2)

Guidance literature:

In tetrahydrofuran; at 70 ℃; for 3h;

DOI:10.1039/b511861a

upstream raw materials:

2-Thiophenecarbonyl chloride

2-(3,4-dimethoxyphenyl)-ethylamine

hex-1-yne

acryloyl chloride