(2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Base Information

Chemical Name:(2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CAS No.:53081-10-0
Molecular Formula:C₁₈H₂₁N₅O₄S
Molecular Weight:403.462
Hs Code.:

Synonyms:(2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

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Chemical Property of (2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

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Technology Process of (2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

There total 6 articles about (2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 23558-62-5
(2R,3R,4S,5R)-2-(6-(benzylamino)-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

: 616-38-6
carbonic acid dimethyl ester

: 53081-10-0
(2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Guidance literature:: With potassium tert-butylate; palladium diacetate; triphenylphosphine; potassium thioacetate; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere;

Reference yield:

: C₂₄H₂₇N₅O₇S

: 53081-10-0
(2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Guidance literature:: With ethanol; sodium;
DOI:10.1016/j.ejmech.2012.03.047

Reference yield:

: 16321-99-6
2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

: 53081-10-0
(2R,3R,4S,5R)-2-(6-(benzylamino)-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 6 h / 60 °C / Inert atmosphere

2.1: triethylamine / ethanol / 8 h / Reflux

3.1: ethanol; sodium

With ethanol; sodium; triethylamine; In ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2012.03.047