(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid

Base Information

Chemical Name:(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid
CAS No.:486459-99-8
Molecular Formula:C₁₆H₁₉F₄NO₄
Molecular Weight:365.325
Hs Code.:

Synonyms:(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid

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Chemical Property of (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid

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Technology Process of (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid

There total 8 articles about (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₁F₄NO₄

: 486459-99-8
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid

Guidance literature:: C₁₇H₂₁F₄NO₄; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 50 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 486460-24-6
C₁₆H₁₇F₄N₃O₃

: 486459-99-8
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid

Guidance literature:: C₁₆H₁₇F₄N₃O₃; With silver benzoate; N-ethyl-N,N-diisopropylamine; In methanol; at 0 ℃; for 2h;

With lithium hydroxide; water; In tetrahydrofuran; methanol; at 50 ℃; for 3h;

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 486460-06-4
(R)-N-(1,1-dimethylethoxycarbonyl)-(2-fluoro-4-trifluoromethyl)phenylalanine

: 486459-99-8
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoic acid

Guidance literature:: (R)-N-(1,1-dimethylethoxycarbonyl)-(2-fluoro-4-trifluoromethyl)phenylalanine; With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.5h;

diazomethane; In tetrahydrofuran; for 16h; Further stages;