(tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

Base Information

Chemical Name:(tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester
CAS No.:102307-11-9
Molecular Formula:C₂₄H₄₅N₁₁O₁₀
Molecular Weight:647.689
Hs Code.:

(tert-butoxycarbonyl)-N<sup>G</sup>-nitroarginyl-N<sup>G</sup>-nitroarginylisoleucine methyl ester

Synonyms:(tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

There total 1 articles about (tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2188-18-3
Boc-Arg(NO₂)-OH

: C₁₃H₂₆N₆O₅*ClH

: 2387-23-7
1,3-Dicyclohexylurea

: 102307-11-9
(tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h;
DOI:10.1021/jm00157a018

Reference yield:

: 102307-11-9
(tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

: 2387-23-7
1,3-Dicyclohexylurea

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 4 N HCl / acetic acid / 0.5 h

2: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In acetic acid;
DOI:10.1021/jm00157a018

Reference yield:

: 102307-11-9
(tert-butoxycarbonyl)-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

: oxymorphone N-(hydrazinocarbonyl)phenylalanylleucylarginylarginylisoleucine methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / 4 N HCl / acetic acid / 0.5 h

2: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

3: 86 percent / 4 N HCl, acetic acid anisole, H₂ / 10percent Pd/C / methanol / 12 h / 760 Torr

4: 78 percent / methanol / 4 h / Heating

With hydrogenchloride; anisole, glacial acetic acid; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; acetic acid;
DOI:10.1021/jm00157a018