(1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene

Base Information

Chemical Name:(1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene
CAS No.:867258-83-1
Molecular Formula:C₃₇H₄₂O₃Si
Molecular Weight:562.824
Hs Code.:

Synonyms:(1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene

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Chemical Property of (1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene

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Technology Process of (1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene

There total 6 articles about (1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 867258-80-8
1,2-anhydro-3,4-di-O-benzyl-6-O-(tert-butyldiphenyl)silyl-5a-carba-β-D-talopyranose

: 867258-83-1
(1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene

Guidance literature:: 1,2-anhydro-3,4-di-O-benzyl-6-O-(tert-butyldiphenyl)silyl-5a-carba-β-D-talopyranose; With iodine; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

With zinc; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2005.07.010

Reference yield:

: 867258-88-6
6-O-(tert-butyldiphenyl)silyl-1,2-di-O-(methoxymethyl)-5a-carba-β-D-talopyranose

: 867258-83-1
(1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0 - 20 °C

1.2: 94.3 percent / tetrahydrofuran / 72 h / 20 °C

2.1: 63 percent / molecular sieves 4 Angstroem; TMSBr / CH₂Cl₂ / 3 h / -20 °C

3.1: pyridinium p-toluenesulfonate; (MeO)3CCH₃ / CH₂Cl₂ / 2 h / 20 °C

3.2: Et₃N; AcBr / CH₂Cl₂ / 3 h / 20 °C

3.3: 91.3 percent / NaOMe / methanol / 0.83 h / 20 °C

4.1: PPh₃; I₂ / dimethylformamide / 0.42 h / 20 °C

4.2: 92 percent / Zn / dimethylformamide / 1 h / 20 °C

With Trimethyl orthoacetate; trimethylsilyl bromide; 4 A molecular sieve; iodine; pyridinium p-toluenesulfonate; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.07.010

Reference yield:

: 867258-79-5
3,4-di-O-benzyl-6-O-(tert-butyldiphenyl)silyl-5a-carba-β-D-talopyranose

: 867258-83-1
(1R,2S,3R)-1,2-di-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohex-5-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium p-toluenesulfonate; (MeO)3CCH₃ / CH₂Cl₂ / 2 h / 20 °C

1.2: Et₃N; AcBr / CH₂Cl₂ / 3 h / 20 °C

1.3: 91.3 percent / NaOMe / methanol / 0.83 h / 20 °C

2.1: PPh₃; I₂ / dimethylformamide / 0.42 h / 20 °C

2.2: 92 percent / Zn / dimethylformamide / 1 h / 20 °C

With Trimethyl orthoacetate; iodine; pyridinium p-toluenesulfonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.07.010