3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid

Base Information

Chemical Name:3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid
CAS No.:1611444-75-7
Molecular Formula:C₂₁H₁₉ClN₄O₂
Molecular Weight:394.86
Hs Code.:

Synonyms:3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid

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Chemical Property of 3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid

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Technology Process of 3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid

There total 4 articles about 3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 25784-58-1
1-benzyl-1H-1,2,3-triazol-5-amine

: 1611444-74-6
ethyl 3-[(2-bromo-5-chlorophenyl)methylene]cyclobutanecarboxylate

: 1611444-75-7
3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid

Guidance literature:: With [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium t-butanolate; tert-butyl XPhos; In tert-butyl alcohol; for 1h; Inert atmosphere; Reflux;

Reference yield:

: 25784-56-9
4-amino-3-benzyl-1,2,3-triazole-5-carboxylic acid

: 1611444-75-7
3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-aniline / 0.33 h / Reflux

2: tert-butyl XPhos; [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium t-butanolate / tert-butyl alcohol / 1 h / Inert atmosphere; Reflux

With [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; N,N-dimethyl-aniline; sodium t-butanolate; tert-butyl XPhos; In tert-butyl alcohol;

Reference yield:

: (2-bromo-5-chlorophenyl)methyltriphenylphosphonium bromide

: 1611444-75-7
3-(2-((1-benzyl-1H-1,2,3-triazol-5-yl)amino)-5-chlorobenzylidene)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

1.2: 24 h / 20 °C

2.1: tert-butyl XPhos; [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium t-butanolate / tert-butyl alcohol / 1 h / Inert atmosphere; Reflux

With [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium hydride; sodium t-butanolate; tert-butyl XPhos; In tetrahydrofuran; tert-butyl alcohol;