((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol

Base Information

Chemical Name:((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol
CAS No.:1416165-38-2
Molecular Formula:C₂₉H₄₇ClO₇Si₃
Molecular Weight:627.397
Hs Code.:

Synonyms:((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol

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Chemical Property of ((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol

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Technology Process of ((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol

There total 1 articles about ((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1416165-39-3
(((2S,3R,4S,5R,6R)-2-(4-chloro-3-(phenoxymethyl)phenyl)-2-methoxy-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl)tris(oxy))tris(trimethylsilane)

: 1416165-38-2
((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol

Guidance literature:: With potassium carbonate; acetic acid; In methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1416165-38-2
((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol

: 1416165-40-6
(2S,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; at 0 - 10 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1416165-38-2
((2R,3R,4S,5R,6S)-6-(4-chloro-3-(phenoxymethyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol

: 1416165-31-5
(1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(3-(4-acetylbenzyl)-4-chlorophenyl)-6,8-dioxabicyclo[3.2.1]octane-2.3,4-triyl triacetate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 3 h / 0 - 10 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 55 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

4: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5: hydrogen bromide; acetic acid / 3 h / 20 °C / Inert atmosphere

6: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Inert atmosphere

With dmap; hydrogen bromide; sodium ethanolate; sulfur trioxide pyridine complex; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;