(R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate

Base Information

Chemical Name:(R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate
CAS No.:1431506-01-2
Molecular Formula:C₁₉H₂₈O₇
Molecular Weight:368.427
Hs Code.:

Synonyms:(R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate

Chemical Property:

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Technology Process of (R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate

There total 4 articles about (R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1431505-94-0
(Z)-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxyacrylate

: 1431506-01-2
(R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate

Guidance literature:: With Rh(I) [(R,R)-Dipamp](COD); hydrogen; In methanol; at 20 ℃; for 96h; under 3750.38 Torr; enantioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201201506

Reference yield:

: 117942-41-3
4-[(2-methoxyethoxy)methoxy]benzaldehyde

: 1431506-01-2
(R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / methanol; diethyl ether / 18 h / 0 - 20 °C

2: hydrogenchloride / water / 0.5 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

4: hydrogen; Rh(I) [(R,R)-Dipamp](COD) / methanol / 96 h / 20 °C / 3750.38 Torr / Inert atmosphere

With hydrogenchloride; Rh(I) [(R,R)-Dipamp](COD); hydrogen; sodium hydride; triethylamine; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1002/ejoc.201201506

Reference yield:

: 1431505-88-2
methyl 2-hydroxy-3-(4-methoxyethoxymethoxyphenyl)acrylate

: 1431506-01-2
(R)-1-methyl 3-(4-(2-methoxyethoxy)methoxyphenyl)-2-pivaloyloxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: hydrogen; Rh(I) [(R,R)-Dipamp](COD) / methanol / 96 h / 20 °C / 3750.38 Torr / Inert atmosphere

With Rh(I) [(R,R)-Dipamp](COD); hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1002/ejoc.201201506