1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole

Base Information

• Chemical Name: 1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole
• CAS No.: 2562-78-9
• Molecular Formula: C₂₀H₁₆N₂
• Molecular Weight: 284.36
• Mol file: 2562-78-9.mol

Synonyms:1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole

Chemical Property of 1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole

There total 7 articles about 1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(4-bromophenyl)-1-methyl-1H-benzo[d]imidazole (2751-84-0) + phenylboronic acid (98-80-6) → 1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole (2562-78-9)

Guidance literature:

With sodium tetrachloropalladate(II); dicyclohexyl {2-sulfo-9-[3-(4-sulfophenyl)propyl]-9H-fluoren-9-yl}phosphonium hydrogen sulfate; potassium carbonate; In water; tert-butyl alcohol; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1055/s-0028-1087383

Reference yield: 92.0%

1-Methylbenzimidazole (1632-83-3) → 1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole (2562-78-9)

Guidance literature:

With nickel(II) triflate; potassium phosphate; 1,2-bis-(dicyclohexylphosphino)ethane; In tert-Amyl alcohol; at 110 ℃;

DOI:10.1039/c5sc02942b

Reference yield: 76.0%

C20H23N2O2Pol + N-methyl-1,2-phenylenediamine (4760-34-3) → 1-methyl-2-(1,1'-biphenyl-4-yl)benzimidazole (2562-78-9)

Guidance literature:

C₂₀H₂₃N₂O₂Pol; With formaldehyd; trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 3h; not specified Inert atmosphere;

N-methyl-1,2-phenylenediamine; In N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.08.095

upstream raw materials:

2-(4-bromophenyl)-1-methyl-1H-benzo[d]imidazole

phenylboronic acid

N-methyl-1,2-phenylenediamine

1-Methylbenzimidazole