(1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide

Base Information

Chemical Name:(1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide
CAS No.:942493-75-6
Molecular Formula:C₁₅H₁₉FN₄O
Molecular Weight:290.34
Hs Code.:

Synonyms:(1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide

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Chemical Property of (1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide

Chemical Property:

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Technology Process of (1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide

There total 4 articles about (1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₉BrFNO

: 942493-75-6
(1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2007.02.054

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 942493-75-6
(1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNH₂ / benzene / 3 h / 20 °C

1.2: benzene / 2 h / 20 °C

1.3: aq. KOH / ethanol / Heating

2.1: AlCl₃ / CH₂Cl₂ / 20 °C

3.1: PPh₃; CBr₄ / dimethylformamide / 1 h / 20 °C

4.1: NaN₃ / dimethylformamide / 20 °C

With aluminium trichloride; sodium azide; carbon tetrabromide; sodium amide; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmcl.2007.02.054

Reference yield:

: 528587-71-5
(1S,5R)-2-oxo-1-(4-fluorophenyl)-3-oxabicyclo[3.1.0]hexane

: 942493-75-6
(1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: AlCl₃ / CH₂Cl₂ / 20 °C

2: PPh₃; CBr₄ / dimethylformamide / 1 h / 20 °C

3: NaN₃ / dimethylformamide / 20 °C

With aluminium trichloride; sodium azide; carbon tetrabromide; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.02.054