3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole

Base Information

• Chemical Name: 3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole
• CAS No.: 1042152-09-9
• Molecular Formula: C₂₅H₃₆N₂O₂SSi
• Molecular Weight: 456.725

Synonyms:3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole

Chemical Property of 3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole

Chemical Property:

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Technology Process of 3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole

There total 2 articles about 3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

→ 3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole (1042152-09-9)

Guidance literature:

Reference yield:

2-Thiophenecarbonyl chloride (5271-67-0) + C20H36N2O2Si (1042151-93-8) → 3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole (1042152-09-9)

Guidance literature:

2-Thiophenecarbonyl chloride; C₂₀H₃₆N₂O₂Si; With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 6h;

With p-toluenesulfonyl chloride; In 1,2-dichloro-ethane; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm800136b

Reference yield: 89.0%

3-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole (1042152-09-9) → 7-phenyl-1-(5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl)-heptan-1-ol (1042152-12-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm800136b

upstream raw materials:

2-Thiophenecarbonyl chloride

C₂₀H₃₆N₂O₂Si

Downstream raw materials:

7-phenyl-1-(5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl)-heptan-1-ol

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